Research Papers: Imaging

Photoacoustic signal amplification through plasmonic nanoparticle aggregation

[+] Author Affiliations
Carolyn L. Bayer

The University of Texas at Austin, Department of Biomedical Engineering, 1 University Station, Austin, Texas 78712

Seung Yun Nam, Yun-Sheng Chen

The University of Texas at Austin, Department of Electrical Engineering, 1 University Station, Austin, Texas 78712

Stanislav Y. Emelianov

The University of Texas at Austin, Department of Biomedical Engineering, 1 University Station, Austin, Texas 78712

The University of Texas at Austin, Department of Electrical Engineering, 1 University Station, Austin, Texas 78712

J. Biomed. Opt. 18(1), 016001 (Jan 03, 2013). doi:10.1117/1.JBO.18.1.016001
History: Received July 20, 2012; Revised October 15, 2012; Accepted November 27, 2012
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Abstract.  Photoacoustic imaging, using targeted plasmonic metallic nanoparticles, is a promising noninvasive molecular imaging method. Analysis of the photoacoustic signal generated by plasmonic metallic nanoparticles is complex because of the dependence upon physical properties of both the nanoparticle and the surrounding environment. We studied the effect of the aggregation of gold nanoparticles on the photoacoustic signal amplitude. We found that the photoacoustic signal from aggregated silica-coated gold nanoparticles is greatly enhanced in comparison to disperse silica-coated gold nanoparticles. Because cellular uptake and endocytosis of nanoparticles results in their aggregation, these results have important implications for the application of plasmonic metallic nanoparticles towards quantitative molecular imaging.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Carolyn L. Bayer ; Seung Yun Nam ; Yun-Sheng Chen and Stanislav Y. Emelianov
"Photoacoustic signal amplification through plasmonic nanoparticle aggregation", J. Biomed. Opt. 18(1), 016001 (Jan 03, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.1.016001


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