Research Papers: Imaging

In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography

[+] Author Affiliations
Lidek Chou

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

OCT Medical Imaging Inc., 1002 Health Sciences Road East, Irvine, California 92612

Andriy Batchinsky, Slava Belenkiy

US Army Institute of Surgical Research, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas 78234

Joseph Jing

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

University of California, Department of Biomedical Engineering, Irvine, California 92697

Tirunelveli Ramalingam

OCT Medical Imaging Inc., 1002 Health Sciences Road East, Irvine, California 92612

Matthew Brenner

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

University of California, Irvine Medical Center, Division of Pulmonary and Critical Care, Orange, California 92868

Zhongping Chen

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612

University of California, Department of Biomedical Engineering, Irvine, California 92697

J. Biomed. Opt. 19(3), 036018 (Mar 24, 2014). doi:10.1117/1.JBO.19.3.036018
History: Received November 18, 2013; Revised February 25, 2014; Accepted February 28, 2014
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Abstract.  We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Lidek Chou ; Andriy Batchinsky ; Slava Belenkiy ; Joseph Jing ; Tirunelveli Ramalingam, et al.
"In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography", J. Biomed. Opt. 19(3), 036018 (Mar 24, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.3.036018


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