Research Papers: Imaging

Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy

[+] Author Affiliations
Yan Wu

Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Cangshan, Fuzhou 350007, China

Jimei University, School of Science, No. 185, Yinjiang Road, Jimei, Xiamen 361021, China

Fangmeng Fu, Chuan Wang

Affiliated Union Hospital of Fujian Medical University, Department of Breast Surgery, No. 29, Xinquan Road, Gulou, Fuzhou 350001, China

Yuane Lian

Affiliated Union Hospital of Fujian Medical University, Department of Pathology, No. 29, Xinquan Road, Gulou, Fuzhou 350001, China

Yuting Nie, Shuangmu Zhuo, Jianxin Chen

Fujian Normal University, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, No. 8, Shangsan Road, Cangshan, Fuzhou 350007, China

J. Biomed. Opt. 20(9), 096007 (Sep 10, 2015). doi:10.1117/1.JBO.20.9.096007
History: Received May 11, 2015; Accepted July 20, 2015
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Abstract.  Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to invasive neoplastic disease. It was found that MPM has the capability to reveal the qualitative changes in features of cells, structure of basement membranes, and architecture of collagens during the development from intraductal carcinoma to invasive ductal carcinoma, as well as the quantitative alterations in nuclear area, circle length of basement membrane, and collagen density. Combined with intra-fiberoptic ductoscopy or transdermal biopsy needle, MPM has the potential to provide immediate histological diagnosis of tumor progression in the field of breast carcinoma.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Yan Wu ; Fangmeng Fu ; Yuane Lian ; Yuting Nie ; Shuangmu Zhuo, et al.
"Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy", J. Biomed. Opt. 20(9), 096007 (Sep 10, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.9.096007


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