Research Papers: Imaging

Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins

[+] Author Affiliations
Brandon S. Nichols, Samuel S. McCachren, III, Nimmi Ramanujam

Duke University, Pratt School of Engineering, Department of Biomedical Engineering, Durham, North Carolina, United States

Antonio Llopis, Ozlem Senlik, David Miller, Martin A. Brooke, Nan M. Jokerst

Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States

Gregory M. Palmer

Duke University Medical Center, Department of Radiation Oncology, Medicine Circle, Durham, North Carolina, United States

Joseph Geradts

Duke University Medical Center, Department of Pathology, Durham, North Carolina, United States

Rachel Greenup

Duke University Medical Center, Department of Surgery, Durham, North Carolina, United States

J. Biomed. Opt. 22(2), 026007 (Feb 22, 2017). doi:10.1117/1.JBO.22.2.026007
History: Received September 23, 2016; Accepted January 26, 2017
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Abstract.  We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4×4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [μs(λ) and μa(λ)] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x, y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2×2  cm2 area in 9  min. The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Brandon S. Nichols ; Antonio Llopis ; Gregory M. Palmer ; Samuel S. McCachren, III ; Ozlem Senlik, et al.
"Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins", J. Biomed. Opt. 22(2), 026007 (Feb 22, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.2.026007


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