In vivo AO-OCT spectral sensitivity and photopigment density measurements of human cone and rod photoreceptors

Marcel T. Bernucci; Yan Liu; James A. Crowell; Qiuzhi Ji; Donald T. Miller

doi:10.1117/12.3003331

13 March 2024 In vivo AO-OCT spectral sensitivity and photopigment density measurements of human cone and rod photoreceptors

Marcel T. Bernucci, Yan Liu, James A. Crowell, Qiuzhi Ji, Donald T. Miller

Author Affiliations +

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240N (2024) https://doi.org/10.1117/12.3003331
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present cone spectral sensitivity and photopigment density measures in the living human eye using adaptive optics optical coherence tomography (AO-OCT) and initial results in rods. AO-OCT optoretinograms after visible light stimulation of variable intensities were acquired. Cones were classified and the mean post-stimulus response to incident retinal energy and wavelength was fit to a power law and related to spectral sensitivity and photopigment density. Individual cone sensitivities showed excellent agreement with ex vivo macaque suction electrophysiology measurements (Baylor 1987). Photopigment density variation and increasing photopigment towards the fovea were consistent with the literature. Rod mean µΔOPL responses trended in the direction of expected rod sensitivity.

Conference Presentation

Citation Download Citation

Marcel T. Bernucci, Yan Liu, James A. Crowell, Qiuzhi Ji, and Donald T. Miller "In vivo AO-OCT spectral sensitivity and photopigment density measurements of human cone and rod photoreceptors", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240N (13 March 2024); https://doi.org/10.1117/12.3003331

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