Zeolite magnetic nano/micro-particles for adsorption, delivery and release of photodynamic dyes

Vladimir Hovhannisyan; Katarina Siposova; Andrej Musatov; Zuzana Mitroova; Shean-Jen Chen

doi:10.1117/12.2526924

22 July 2019 Zeolite magnetic nano/micro-particles for adsorption, delivery and release of photodynamic dyes

Vladimir Hovhannisyan, Katarina Siposova, Andrej Musatov, Zuzana Mitroova, Shean-Jen Chen

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110751G (2019) https://doi.org/10.1117/12.2526924
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Adsorption of photodynamic active dyes (hypericin, chlorin e₆, methylene blue, ALA and fluorescein) and they release from clinoptilolite type of zeolite (CZ) in the presence of biomolecules, such as collagen, albumin and hemoglobin, were quantitatively investigated by absorption and fluorescence spectrometry. Using multiphoton microscopy, we demonstrated that effective inducing of two-photon excited luminescence and second harmonic generation signals in nano/micro-particles of CZ by femtosecond near-infrared laser excitation can be successfully utilized in multiphoton imaging of CZ particles and the dye adsorption processes. In addition, CZ magnetic (MCZ) particles were fabricated and proposed as a promising material for drug delivery and controlled release in biological systems. It is shown that the temperature of the aqueous suspension of MCZ of 2 cm³ can be increased by 7 ºC for 3 minutes by an induction heater. Furthermore, it was demonstrated that MCZ particles have strong inhibition and destruction effects on insulin and lysozyme fibrillization, and the protein amyloid formation is inhibited in a dose-dependent manner. Optical spectrometry and multiphoton microscopy are effective approaches that may reveal potential of magnetic zeolites in drug delivery and biomedical imaging of cancer photodynamic therapy and hyperthermia.

Citation Download Citation

Vladimir Hovhannisyan, Katarina Siposova, Andrej Musatov, Zuzana Mitroova, and Shean-Jen Chen "Zeolite magnetic nano/micro-particles for adsorption, delivery and release of photodynamic dyes", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751G (22 July 2019); https://doi.org/10.1117/12.2526924

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