Neuronal electrical activity induced by optical trapping of neurotransmitter receptors on neuron

Tatsunori Kishimoto; Suguru N. Kudoh; Takahisa Taguchi; Chie Hosokawa

doi:10.1117/12.2573759

15 June 2020 Neuronal electrical activity induced by optical trapping of neurotransmitter receptors on neuron

Tatsunori Kishimoto, Suguru N. Kudoh, Takahisa Taguchi, Chie Hosokawa

Proceedings Volume 11522, Optical Manipulation and Structured Materials Conference 2020; 1152217 (2020) https://doi.org/10.1117/12.2573759
Event: SPIE Technologies and Applications of Structured Light, 2020, Yokohama, Japan

Abstract

AMPA-type glutamate receptor (AMPAR) is one of neurotransmitter receptors at excitatory synapses in neuronal cell. For realizing the artificial control of synaptic transmission, we have applied optical trapping of quantum-dot (QD) conjugated AMPARs on neuronal cells. Here, we demonstrate simultaneous measurement combined with optical trapping and patch-clamp recordings to evaluate the neuronal electrical activity. The relationship between optical trapping dynamics of QD-AMPARs located on neuronal cells and the neuronal electrical activity was discussed.

Citation Download Citation

Tatsunori Kishimoto, Suguru N. Kudoh, Takahisa Taguchi, and Chie Hosokawa "Neuronal electrical activity induced by optical trapping of neurotransmitter receptors on neuron", Proc. SPIE 11522, Optical Manipulation and Structured Materials Conference 2020, 1152217 (15 June 2020); https://doi.org/10.1117/12.2573759

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