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27 November 2023 Spatial differential distribution of connective cells in two different tumor-associated collagen signatures at the breast cancer boundary
Zhijun Li, Xi Chen, Shuoyu Xu, Wenhui Guo, Lianhuang Li, Xiahui Han, Liqin Zheng, Deyong Kang, Jianxin Chen, Shunwu Xu, Jianhua Chen
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Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127700S (2023) https://doi.org/10.1117/12.2687023
Event: SPIE/COS Photonics Asia, 2023, Beijing, China
Abstract
The invasion and metastasis of tumor cells are not only related to the tumor cells themselves, but also closely intertwined with other components of the tumor microenvironment. The connective cells, including fibroblasts and myofibroblasts, play a crucial role in determining the remodeling of collagen fibers in the tumor microenvironment during the process of tumor invasion, which determinant of tumor migration. In this study, we used the multi-photon imaging system to identify two different prognostic tumor-associated collagen signatures (TACS4 and TACS6). Then, the multi-photon images were used to co-locate with HE images, and open-source convolutional neural network Hover-Net was used to segment, classify and quantifythe nuclear feature. Our results showed that the connective cells are opposed to tumor cells and do not mix with tumor cells in TACS4, while in TACS6, they are scattered promiscuously with tumor cells. The spatial distribution of connected cells in TACS4 is denser than that in TACS6. These differences in spatial distribution of connected cells may potentially have different prognostic information.
(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Zhijun Li, Xi Chen, Shuoyu Xu, Wenhui Guo, Lianhuang Li, Xiahui Han, Liqin Zheng, Deyong Kang, Jianxin Chen, Shunwu Xu, and Jianhua Chen "Spatial differential distribution of connective cells in two different tumor-associated collagen signatures at the breast cancer boundary", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127700S (27 November 2023); https://doi.org/10.1117/12.2687023
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KEYWORDS
Tumors
Collagen
Breast cancer
Image segmentation
Second harmonic generation
Imaging systems
Cancer
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