Retention of tin ethyl etiopurpurin (SnET2) by atheromatous plaques: studies in vitro and in vivo rabbit

Hugh L. Narciso Jr.; Wai-Fung Cheong; Richard J. Crilley; Daniel R. Doiron; J. Richard Spears M.D.

doi:10.1117/12.179927

12 July 1994 Retention of tin ethyl etiopurpurin (SnET2) by atheromatous plaques: studies in vitro and in vivo rabbit

Hugh L. Narciso Jr., Wai-Fung Cheong, Richard J. Crilley, Daniel R. Doiron, J. Richard Spears M.D.

Proceedings Volume 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV; (1994) https://doi.org/10.1117/12.179927
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Restenosis remains the greatest limitation to the success of conventional and newer forms of angioplasty for the treatment of coronary artery disease. Since the armamentarium available to the clinician is presently limited to mechanical forms of intervention, invariably causing an acute response to injury, a pharmacologic alternative is sought. Photodynamic therapy has the potential to provide a combined drug/device therapy to significantly reduce the rate of restenosis through selective cytolysis and cytostasis. In this study Tin Ethyl Etiopurpurin, a second generation photosensitizer, demonstrated selective retention in catheter induced atheromatous plaques in a New Zealand White rabbit model in vitro and in vivo.

Citation Download Citation

Hugh L. Narciso Jr., Wai-Fung Cheong, Richard J. Crilley, Daniel R. Doiron, and J. Richard Spears M.D. "Retention of tin ethyl etiopurpurin (SnET2) by atheromatous plaques: studies in vitro and in vivo rabbit", Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); https://doi.org/10.1117/12.179927

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available