Identification of junction structures during lung development

Robert R. Goldberg; Michael R. Goldberg

doi:10.1117/12.326981

6 October 1998 Identification of junction structures during lung development

Robert R. Goldberg, Michael R. Goldberg

Proceedings Volume 3521, Machine Vision Systems for Inspection and Metrology VII; (1998) https://doi.org/10.1117/12.326981
Event: Photonics East (ISAM, VVDC, IEMB), 1998, Boston, MA, United States

Abstract

An algorithm is developed to determine the significant junction points of branching tubules during embryonic lung development. This algorithm involves a multidisciplinary approach to preprocessing the input data so that it is ready for such analysis. In addition to specific biochemical techniques employed (such as fluorescent staining), a number of image processing methods are utilized to remove noise and insignificant structures in the image. The final junction analysis is performed on the skeleton of the major branches using a variation of the medial axis transform. The significance of this research is both to enable searches in digital libraries of such biological data for branching during lung development as well as indicating to the biologist the important sites to consider for further investigation.

Citation Download Citation

Robert R. Goldberg and Michael R. Goldberg "Identification of junction structures during lung development", Proc. SPIE 3521, Machine Vision Systems for Inspection and Metrology VII, (6 October 1998); https://doi.org/10.1117/12.326981

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