Determination of single-pulse exposure threshold (ED50) for cornea for 1400- to 2000-nm lasers

Thomas E. Johnson; Thomas A. Eggleston; David J. Fletcher D.V.M.; Ken Lopez; Pedro J. Rico; Michael A. Mitchell; William P. Roach

doi:10.1117/12.350045

14 June 1999 Determination of single-pulse exposure threshold (ED₅₀) for cornea for 1400- to 2000-nm lasers

Thomas E. Johnson, Thomas A. Eggleston, David J. Fletcher D.V.M., Ken Lopez, Pedro J. Rico, Michael A. Mitchell, William P. Roach

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Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350045
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We report on preliminary work undertaken to determine ED₅₀ thresholds for both skin and cornea exposure from 1400 to 2000 nm laser light. Work presented here is focused initially on 1540 nm exposures to both human skin and cornea. Light microscopy and confocal microscopy used to help understand the type of photon-tissue interactions responsible for skin and corneal injury are discussed along with preliminary results from these techniques. Further, we report on in vivo models which are considered to best represent human skin for laser tissue interaction studies. Additionally, in vitro models for corneal exposure are discussed as replacement models for in vivo corneal exposures.

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Thomas E. Johnson, Thomas A. Eggleston, David J. Fletcher D.V.M., Ken Lopez, Pedro J. Rico, Michael A. Mitchell, and William P. Roach "Determination of single-pulse exposure threshold (ED₅₀) for cornea for 1400- to 2000-nm lasers", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350045

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KEYWORDS

Skin

Cornea

Cameras

In vivo imaging

Confocal microscopy

Laser damage threshold

Laser tissue interaction

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