Laser-induced fluorescence for the detection of esophageal and skin cancer

Tuan Vo-Dinh; Masoud Panjehpour; Bergein F. Overholt M.D.; Clark E. Julius M.D.; Suzanne Overholt; Mary N. Phan

doi:10.1117/12.488678

22 July 2003 Laser-induced fluorescence for the detection of esophageal and skin cancer

Tuan Vo-Dinh, Masoud Panjehpour, Bergein F. Overholt M.D., Clark E. Julius M.D., Suzanne Overholt, Mary N. Phan

Proceedings Volume 4958, Advanced Biomedical and Clinical Diagnostic Systems; (2003) https://doi.org/10.1117/12.488678
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Laser-induced fluorescence (LIF) is used for in-vivo cancer diagnosis of the esophagus and skin cancer. For esophageal measurements a fiberoptic probe inserted through an endoscope was used. Autofluorescence of normal and malignant tissues were measured directly on patient skin without requiring an endoscope. Measurement of the fluorescence signal from the tissue was performed using laser excitation at 410 nm. The methodology was applied to differentiate normal and malignant tumors of the esophagus and malignant skin lesions. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated.

Citation Download Citation

Tuan Vo-Dinh, Masoud Panjehpour, Bergein F. Overholt M.D., Clark E. Julius M.D., Suzanne Overholt, and Mary N. Phan "Laser-induced fluorescence for the detection of esophageal and skin cancer", Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); https://doi.org/10.1117/12.488678

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