Photoacoustic diagnosis of edema in rat burned skin

Ken Yoshida; Shunichi Sato; Kosuke Hatanaka; Daizoh Saitoh; Hiroshi Ashida; Toshihisa Sakamoto; Minoru Obara

doi:10.1117/12.841438

23 February 2010 Photoacoustic diagnosis of edema in rat burned skin

Ken Yoshida, Shunichi Sato, Kosuke Hatanaka, Daizoh Saitoh, Hiroshi Ashida, Toshihisa Sakamoto, Minoru Obara

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 75641C (2010) https://doi.org/10.1117/12.841438
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Diagnosis of edema, abnormal accumulation of water in tissue, is important for managing various traumatic injuries and diseases. However, there is no established method for real-time, noninvasive monitoring of edema. In severe extensive burn injuries, edema develops both topically and systemically due to the increased permeability of blood vessels. In this study, we examined photoacoustic (PA) monitoring of edema formed in rat burn models. Deep dermal burn with a 20% total body surface area was made in the dorsal skin of rats. Burn and its adjacent nonburn tissues were irradiated with 6-ns light pulses at 1430 nm, which is one of the absorption peak wavelengths of water in the near infrared. The PA signal amplitude increased until 12 - 24 hr postburn, and thereafter it gradually decreased to its initial level; the latter phase (after 24 hr postburn) coincided with a diuretic phase in the rats. There was a significant correlation between the PA signal amplitudes and water contents in the tissue measured by wet/dry weight method. These findings demonstrate the validity of PA measurement for real-time, noninvasive monitoring of edema.

Citation Download Citation

Ken Yoshida, Shunichi Sato, Kosuke Hatanaka, Daizoh Saitoh, Hiroshi Ashida, Toshihisa Sakamoto, and Minoru Obara "Photoacoustic diagnosis of edema in rat burned skin", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641C (23 February 2010); https://doi.org/10.1117/12.841438

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available