Resolution study of imaging in nanoparticle optical phantoms

E. Ortiz-Rascón; N. C. Bruce; J. O. Flores-Flores; R. Sato-Berru

doi:10.1117/12.903097

2 November 2011 Resolution study of imaging in nanoparticle optical phantoms

E. Ortiz-Rascón, N. C. Bruce, J. O. Flores-Flores, R. Sato-Berru

Proceedings Volume 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World; 801190 (2011) https://doi.org/10.1117/12.903097
Event: International Commission for Optics (ICO 22), 2011, Puebla, Mexico

Abstract

We present results of resolution and optical characterization studies of silicon dioxide nanoparticle solutions. These phantoms consist of spherical particles with a mean controlled diameter of 168 and 429 nm. The importance of this work lies in using these solutions to develop phantoms with optical properties that closely match those of human breast tissue at near-IR wavelengths, and also to compare different resolution criteria for imaging studies at these wavelengths. Characterization involves illuminating the solution with a laser beam transmitted through a recipient of known width containing the solution. Resulting intensity profiles from the light spot are measured as function of the detector position. Measured intensity profiles were fitted to the calculated profiles obtained from diffusion theory, using the method of images. Fitting results give us the absorption and transport scattering coefficients. These coefficients can be modified by changing the particle concentration of the solution. We found that these coefficients are the same order of magnitude as those of human tissue reported in published studies. The resolution study involves measuring the edge response function (ERF) for a mask embedded on the nanoparticle solutions and fitting it to the calculated ERF, obtaining the resolution for the Hebden, Sparrow and Bentzen criteria.

Citation Download Citation

E. Ortiz-Rascón, N. C. Bruce, J. O. Flores-Flores, and R. Sato-Berru "Resolution study of imaging in nanoparticle optical phantoms", Proc. SPIE 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World, 801190 (2 November 2011); https://doi.org/10.1117/12.903097

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