Probing microscopic mechanical properties of hard tissues with Brillouin spectroscopy

Zhaokai Meng; Vladislav V. Yakovlev

doi:10.1117/12.2080334

6 April 2015 Probing microscopic mechanical properties of hard tissues with Brillouin spectroscopy

Zhaokai Meng, Vladislav V. Yakovlev

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 930342 (2015) https://doi.org/10.1117/12.2080334
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Mechanical properties of hard tissues play an important role in understanding underlying biological structures, as well as assessing the quality of artificial bone replacement materials. In this study, we employed Brillouin spectroscopy as a non-invasive approach to probe the microscopic elasticity of hard tissues, such as bones. Brillouin spectra were collected using a background free virtually imaged phased array spectrometer. As a reference, Raman spectra were also acquired for each imaging point. Experimental results reveal a positive correlation between the local concentration of the mineral content and the corresponding tissue stiffness, assessed through a Brillouin shift.

Citation Download Citation

Zhaokai Meng and Vladislav V. Yakovlev "Probing microscopic mechanical properties of hard tissues with Brillouin spectroscopy", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 930342 (6 April 2015); https://doi.org/10.1117/12.2080334

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