Dr. Emilie Krite Svanberg Profile

Dr. Emilie Krite Svanberg

Resident Doctor at Lund Univ

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Publications (4)

Proceedings Article | 20 November 2019 Paper

Simulation of near-infrared light propagation through the thorax of a neonate: addressing the optimisation of source and detector positions for measuring lung oxygen content in preterm infants

Andrea Pacheco, Emilie Krite Svanberg, Eugene Dempsey, Stefan Andersson-Engels

Proceedings Volume 11190, 111901C (2019) https://doi.org/10.1117/12.2537875

KEYWORDS: Lung, Sensors, Light, Oxygen, Absorption, Image segmentation, 3D modeling, Light sources, Tissue optics, Skin

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Gas in scattering media absorption spectroscopy shortly called GASMAS, is a tunable diode laser spectroscopic technique developed for the measurement of gas present in turbid media. The technique relies on the sharp and specific absorption lines of gases which enables sensitive measurements of gas concentrations in the presence of a scattering solid medium with much broader absorption features. The Biophotonics laboratory at Tyndall National Institute (Biophotonics@Tyndall) is currently exploring the clinical translation of GASMAS technology into the respiratory healthcare of neonates. In this study, we use computational tools to assess the potential gain in gas absorption signal. One of the challenges in the development of the GASMAS technique is to obtain a sufficiently good signal in the measurements, as the light attenuation is high in tissue and the lungs are interior organs. To have an estimation of the capabilities and limitations in this specific application of gas spectroscopy, we model the transmission of near infrared (NIR) light in tissue when a 760 nm source and a set of 68 detectors are placed in different locations over the thorax. We segmented the main organs of the thorax from anonymized DICOM images of a neonate. This is followed by the creation of 3D computational models to solve light propagation with the diffusion equation, and the modelling of light propagation through the thorax of an infant including optical properties of lung, heart, arteries, bone, muscle, trachea, fat and skin. Finally, we calculate a map of the optimal light source – detector configurations to obtain the highest signal from oxygen gas imprint in the lungs. The use of computational tools such as NIRFAST Slicer 2.0 for investigation and further understanding of the advantages and limitations of the technology is fundamental.

Such simulations enable the recreation of different clinical scenarios and identification of the minimum requirements necessary to further improve the application and develop a bedside clinical device that can potentially be used for continuous monitoring of lung function and control of ventilator settings. The potential capability of measuring non-invasively oxygen, water vapour and carbon dioxide in the lungs, would reduce the need for intubation and extracorporeal membrane oxygenation, as well as lower the incidences of chronic lung disease.

SPIE Journal Paper | 20 December 2013 Open Access

Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study

Patrik Lundin, Emilie Krite Svanberg, Lorenzo Cocola, Märta Lewander Xu, Gabriel Somesfalean, Stefan Andersson-Engels, John Jahr, Vineta Fellman, Katarina Svanberg, Sune Svanberg

JBO, Vol. 18, Issue 12, 127005, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.127005

KEYWORDS: Lung, Absorption, Intestine, Oxygen, Sensors, Tissue optics, Signal detection, Ultrasonography, Tissues, Monte Carlo methods

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Proceedings Article | 18 November 2013 Paper

Muscle tissue saturation in humans studied with two non-invasive optical techniques: a comparative study

Alfi Shaharin, Emilie Krite Svanberg, Ida Ellerström, Arman Ahamed Subash, Dmitry Khoptyar, Stefan Andersson-Engels, Jonas Åkeson

Proceedings Volume 9032, 90320K (2013) https://doi.org/10.1117/12.2044799

KEYWORDS: Tissues, Scattering, Tissue optics, Absorption, Sensors, Oxygen, Light scattering, Optical properties, Solids, Blood

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Proceedings Article | 3 February 2012 Paper

Non-invasive gas monitoring in newborn infants using diode laser absorption spectroscopy: a case study

Patrik Lundin, Emilie Svanberg, Lorenzo Cocola, Märta Lewander, Stefan Andersson-Engels, John Jahr, Vineta Fellman, Katarina Svanberg, Sune Svanberg

Proceedings Volume 8229, 822903 (2012) https://doi.org/10.1117/12.907464

KEYWORDS: Lung, Oxygen, Intestine, Absorption, Tissue optics, Sensors, Signal detection, Semiconductor lasers, Monte Carlo methods, Absorption spectroscopy

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