Sample-to-answer nucleic acid testing device for point of care infectious disease screening

Weihua Guan

doi:10.1117/12.3005535

13 March 2024 Sample-to-answer nucleic acid testing device for point of care infectious disease screening

Weihua Guan

Proceedings Volume PC12837, Microfluidics, BioMEMS, and Medical Microsystems XXII; PC1283709 (2024) https://doi.org/10.1117/12.3005535
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Nucleic acid testing (NAT) is currently the most sensitive method available for identifying infectious pathogens. Nevertheless, NAT-based diagnoses developed to date mostly require sophisticated infrastructures, reagents, and skilled technicians. While readily available in reference laboratories, NATs such as PCR remain inaccessible in resource-limited settings. Although extensive efforts have been undertaken toward point-of-care (POC) molecular diagnosis, a fully validated ‘sample-in-answer-out’ NAT system has not developed due to significant challenges of portability, sample preparation, and throughput. In this talk, I will discuss several low-cost field-deployable NAT devices and systems developed in our lab in the past 8 years, especially for infectious diseases in resource-limiting areas. These NAT devices could be loaded with easily-obtainable raw samples such as finger-prick blood, making diagnostic testing faster and easier for identifying pathogens like Malaria, HIV and SARS-COV-2.

Conference Presentation

Citation Download Citation

Weihua Guan "Sample-to-answer nucleic acid testing device for point of care infectious disease screening", Proc. SPIE PC12837, Microfluidics, BioMEMS, and Medical Microsystems XXII, PC1283709 (13 March 2024); https://doi.org/10.1117/12.3005535

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KEYWORDS

Point-of-care devices

Diseases and disorders

Nucleic acids

Education and training

Polymerase chain reaction

Portability

Biological samples

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