Development of near infrared contrast agents for non-invasive early-stage cancer detection

Grace E. Hubbell; Riley Whalen; Heather Theison; Joshua Pace; Junxiong Ma; Melissa H. Wong; Mark Niedre; Lei G. Wang; Summer L. Gibbs

doi:10.1117/12.3003333

13 March 2024 Development of near infrared contrast agents for non-invasive early-stage cancer detection

Grace E. Hubbell, Riley Whalen, Heather Theison, Joshua Pace, Junxiong Ma, Melissa H. Wong, Mark Niedre, Lei G. Wang, Summer L. Gibbs

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Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC1286204 (2024) https://doi.org/10.1117/12.3003333
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Cancer remains one of the leading causes of death worldwide despite advances in diagnostic and treatment approaches. Current methods of detection and diagnosis remain inaccessible or expensive in nature; therefore, the development of non-invasive strategies towards early-stage cancer detection are important to allow for early intervention, treatment, and access. Liquid biopsies have emerged as a non-invasive source to improve routine cancer monitoring, however cancer biomarker abundance is low, leading to limitations in detection and accuracy. The recent discovery of neoplastic circulating hybrid cells (CHCs) in peripheral patient blood provide the potential to improve detection sensitivity of blood-based assays using novel molecular-targeting contrast agents specific to both circulating tumor cells (CTCs) and CHCs. Additionally, these contrast agents can be detected using diffuse in vivo flow cytometry (DiFC), enabling non-invasive enumeration of cancer cell burden. Herein, the development and validation of near infrared (NIR) molecularly-targeted contrast agents with specificity towards epithelial biomarkers expressed on CHC and CTCs is discussed.

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Grace E. Hubbell, Riley Whalen, Heather Theison, Joshua Pace, Junxiong Ma, Melissa H. Wong, Mark Niedre, Lei G. Wang, and Summer L. Gibbs "Development of near infrared contrast agents for non-invasive early-stage cancer detection", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC1286204 (13 March 2024); https://doi.org/10.1117/12.3003333

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KEYWORDS

Cancer detection

Contrast agents

Near infrared

Cancer

Blood

Diagnostics

Flow cytometry

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