In-vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer

V. V. Klimenko; S. V. Shmakov; N. E. Kaydanov; N. A. Knyazev; N. V. Kazakov; A. A. Rusanov; A. A. Bogdanov; M. V. Dubina

doi:10.1117/12.2286457

1 August 2017 In-vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer

V. V. Klimenko, S. V. Shmakov, N. E. Kaydanov, N. A. Knyazev, N. V. Kazakov, A. A. Rusanov, A. A. Bogdanov, M. V. Dubina

Author Affiliations +

Proceedings Volume 10417, Medical Laser Applications and Laser-Tissue Interactions VIII; 1041703 (2017) https://doi.org/10.1117/12.2286457
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

In this present study we investigate the Radachlorin photosensitizer accumulation in K562 cells and Hela cells and determined the cell viability after PDT. Using the macroscopic singlet oxygen modeling and cellular photosensitizer concentration the singlet oxygen threshold doses for K562 cells and Hela cells were calculated.

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V. V. Klimenko, S. V. Shmakov, N. E. Kaydanov, N. A. Knyazev, N. V. Kazakov, A. A. Rusanov, A. A. Bogdanov, and M. V. Dubina "In-vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer", Proc. SPIE 10417, Medical Laser Applications and Laser-Tissue Interactions VIII, 1041703 (1 August 2017); https://doi.org/10.1117/12.2286457

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