Optimization of the incident wavelength in Mueller matrix imaging of cervical collagen

Joseph Chue-Sang; Jessica C. Ramella-Roman

doi:10.1117/12.2290766

2 March 2018 Optimization of the incident wavelength in Mueller matrix imaging of cervical collagen

Joseph Chue-Sang, Jessica C. Ramella-Roman

Proceedings Volume 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV; 1047809 (2018) https://doi.org/10.1117/12.2290766
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Mueller matrix polarimetry (MMP) can be utilized to determine optical anisotropy in birefringent materials. Many factors must be optimized to improve the quality of information collected from MMP of biological samples. As part of a study of pre-term birth (PTB) that relied on measurement of the orientation and distribution of collagen in the cervix, an optimal wavelength for MMp to allow more accurate characterization of collagen in cervical tissue was sought. To this end, we developed a multispectral Mueller matrix polarimeter and conducted experiments on ex-vivo porcine cervix samples preserved in paraffin. The Mueller matrices obtained with this system were decomposed to generate orientation and retardation images. Initial findings indicate that wavelengths below 560 nm offer a more accurate characterization of collagen anisotropy in the porcine cervix.

Conference Presentation

Citation Download Citation

Joseph Chue-Sang and Jessica C. Ramella-Roman "Optimization of the incident wavelength in Mueller matrix imaging of cervical collagen", Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 1047809 (2 March 2018); https://doi.org/10.1117/12.2290766

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