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7 December 2017 Implicit dosimetry of microorganism photodynamic inactivation
Mindaugas Tamošiūnas, Neringa Kuliešienė, Rimantas Daugelavičius
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Proceedings Volume 10592, Biophotonics—Riga 2017; 105920K (2017) https://doi.org/10.1117/12.2297221
Event: The Second International Conference "Biophotonics-Riga 2017", 2017, Riga, Latvia
Abstract
Photosensitization based antibacterial treatment is efficient against a broad range of pathogens but it utilizes suboptimal dosimetry with an explicit (and very broad range) determination of sensitizer concentration, light dose and fluence rates. In this study we verified the implicit dosimetry approach for pathogen photodynamic treatment, employing protoporphyrin IX (ppIX) photobleaching to assess the killing efficacy against Staphylococcus aureus and Candida albicans cells. The results show that there was an increased kill of S. aureus and C. albicans at higher degree of ppIX fluorescence decay. Therefore ppIX photobleaching can be incorporated into the PDI dose metric offering to predict the pathogen killing efficacy during photodynamic treatment.
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Mindaugas Tamošiūnas, Neringa Kuliešienė, and Rimantas Daugelavičius "Implicit dosimetry of microorganism photodynamic inactivation", Proc. SPIE 10592, Biophotonics—Riga 2017, 105920K (7 December 2017); https://doi.org/10.1117/12.2297221
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KEYWORDS
Luminescence
Microorganisms
Pathogens
Biochemistry
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