Highly localized laser-induced vascular responses

Elena S. Stiukhina; Maxim A. Kurochkin; Ivan V. Fedosov; Dmitry E. Postnov

doi:10.1117/12.2315072

26 April 2018 Highly localized laser-induced vascular responses

Elena S. Stiukhina, Maxim A. Kurochkin, Ivan V. Fedosov, Dmitry E. Postnov

Proceedings Volume 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV; 107171Z (2018) https://doi.org/10.1117/12.2315072
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

The assessment of functioning microcirculatory network implies usage of adequate tools for testing the network responses on local changes of vessels state. While there are well-developed and widely used methods, such as focal application of vasoactive substances, or electric stimulation, there is a need for a non-destructive (and ideally – non-contact) and local method of impact a single vessel in order to trigger the network responce.

In this paper, we investigate the possibility of applying the effect of a reversible change in the diameter of a blood vessel caused by laser radiation as a functional test of a microcirculatory system. For this purpose, we combine this effect with the method of micro-PIV (particle image velocimetry), which provides information on both the dynamics of blood flow in neighboring segments and the changes in their diameters.

Citation Download Citation

Elena S. Stiukhina, Maxim A. Kurochkin, Ivan V. Fedosov, and Dmitry E. Postnov "Highly localized laser-induced vascular responses", Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 107171Z (26 April 2018); https://doi.org/10.1117/12.2315072

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KEYWORDS

Blood

Blood circulation

Blood vessels

Laser irradiation

Image segmentation

Nondestructive evaluation

Absorption

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