Cristina Kurachi,1 Natalia Mayumi Inada,1 Lilian Tan Moriyama,1 Cynthia Aparecida de Castro,1 Renata A. Belotto,2 Wellington Lombardi,1 Vanderlei Salvador Bagnato1
1Instituto de Física de São Carlos (Brazil) 2UNINOVE (Brazil)
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Cervical intraneoplasia (CIN), during its progression, shows an increased cell atypia and affects thicker epithelial structure. Photodynamic therapy (PDT) may constitute an attractive minimally invasive treatment technique. CIN mostly occurs at the squamous-columnar junction (SCJ) of the cervix, resulting in a challenge to achieve the aimed PDT uniform photosensitizer distribution and irradiation. The development of the clinical protocol and of the customized optical treatment probe is essential for an improved PDT response for CIN 1,2 and 3. Results of the developed instrumentation in an ongoing clinical study will be discussed.
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Cristina Kurachi, Natalia Mayumi Inada, Lilian Tan Moriyama, Cynthia Aparecida de Castro, Renata A. Belotto, Wellington Lombardi, Vanderlei Salvador Bagnato, "Strategies for an improved PDT for cervix (Conference Presentation)," Proc. SPIE 10856, Diseases in the Breast and Reproductive System V, 108560A (13 March 2019); https://doi.org/10.1117/12.2514616