In vivo quantification of nitric oxide (NO) release from intact human skin following exposure to photobiomodulation wavelengths in the visible and near infrared spectrum

Augustin C. Barolet; Gregory Cormack; Gabriel Lachance; Mathieu Auclair; Daniel Barolet

doi:10.1117/12.2508707

7 March 2019 In vivo quantification of nitric oxide (NO) release from intact human skin following exposure to photobiomodulation wavelengths in the visible and near infrared spectrum

Augustin C. Barolet, Gregory Cormack, Gabriel Lachance, Mathieu Auclair, Daniel Barolet

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Proceedings Volume 10861, Mechanisms of Photobiomodulation Therapy XIV; 108610G (2019) https://doi.org/10.1117/12.2508707
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Human skin contains photolabile nitric oxide (NO) derivatives which decompose after UVA irradiation and release vasoactive NO. However, aside from blue light, barely nothing has been reported about the effects of red and NIR wavelengths. We decided to investigate if photobiomodulation, using visible to NIR light, would increase the release of NO in the skin. A custom-built airtight sleeve which envelopes the forearm of a subject was used to measure the NO emanating from the skin under photobiomodulation conditions and quantified by chemiluminescence detection. Distinct differences in measured NO levels were observed between the non-irradiated condition and PBM conditions.

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Augustin C. Barolet, Gregory Cormack, Gabriel Lachance, Mathieu Auclair, and Daniel Barolet "In vivo quantification of nitric oxide (NO) release from intact human skin following exposure to photobiomodulation wavelengths in the visible and near infrared spectrum", Proc. SPIE 10861, Mechanisms of Photobiomodulation Therapy XIV, 108610G (7 March 2019); https://doi.org/10.1117/12.2508707

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