Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment  (Conference Presentation)

Yan Liu; Yuecheng Shen; Haowen Ruan; Frank L. Brodie; Terence T. W. Wong; Changhuei Yang; Lihong V. Wang

doi:10.1117/12.2508994

4 March 2019 Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)

Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, Lihong V. Wang

Author Affiliations +

Proceedings Volume 10886, Adaptive Optics and Wavefront Control for Biological Systems V; 1088602 (2019) https://doi.org/10.1117/12.2508994
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode, we focused 532 nm light through a highly scattering ex vivo adult human cataractous lens of 112 mean free path thick. This work demonstrates a potential clinical application of wavefront shaping techniques.

Conference Presentation

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Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, and Lihong V. Wang "Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)", Proc. SPIE 10886, Adaptive Optics and Wavefront Control for Biological Systems V, 1088602 (4 March 2019); https://doi.org/10.1117/12.2508994

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KEYWORDS

Scattering

Lenses

Surgery

Light scattering

Retina

Wavefronts

Opacity

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