Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

Pranav Lanka; K. J. Francis; Hindrik Kruit; Sanathana Konugolu Venkata Sekar; Andrea Farina; Rinaldo Cubeddu; Srirang Manohar; Antonio Pifferi

doi:10.1117/12.2526964

11 July 2019 Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

Pranav Lanka, K. J. Francis, Hindrik Kruit, Sanathana Konugolu Venkata Sekar, Andrea Farina, Rinaldo Cubeddu, Srirang Manohar, Antonio Pifferi

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110742M (2019) https://doi.org/10.1117/12.2526964
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Radiofrequency ablation (RFA) is minimally invasive thermotherapy, where a heating source is used to target and kill malignant cells in a tissue. While RFA has tremendous potential in the field of oncology, there is also a need for reliable real-time monitoring of this procedure to avoid over or under treatment. In this work, we investigate the use of timeresolved diffuse optical spectroscopy (DOS) to continuously track the change in optical properties during RFA to monitor the process of ablation. The time evolution of the spectra of the optical properties of the tissue undergoing treatment gives deep insights into the structural and constitutional changes occurring during the RFA treatment.

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Pranav Lanka, K. J. Francis, Hindrik Kruit, Sanathana Konugolu Venkata Sekar, Andrea Farina, Rinaldo Cubeddu, Srirang Manohar, and Antonio Pifferi "Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742M (11 July 2019); https://doi.org/10.1117/12.2526964

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