UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats

Yunqi Li; Haixia Qiu; Hongyou Zhao; Biao Chang; Tengda Ji M.D.; Yidi Liu; Ying Gu

doi:10.1117/12.2537833

20 November 2019 UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats

Yunqi Li, Haixia Qiu, Hongyou Zhao, Biao Chang, Tengda Ji M.D., Yidi Liu, Ying Gu

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 111903A (2019) https://doi.org/10.1117/12.2537833
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Osteoporosis is a bone disease associated with aging. As the population ages, osteoporosis has become a significant public health problem that threaten life quality of most countries in the world. Adequate vitamin D is able to improve intestinal calcium absorption, promote bone mineralization, maintain muscle strength, enhance balancing ability, and reduce fall risks, whichplays a vital role in bone metabolism. Moreover, vitamin D is mainly produced by ultraviolet (UV) light. The serum levels of 25(OH)D3 is the tools for estimating of the osteoporosis.It is known that vitamin D deficiency is ubiquitous in the elderly population, hence, we adopted UV light-emitting diode (UV-LED) instruments to generate narrow-range wavelengths of UV and determined its capability for producing vitamin D. The osteoporosis SD rats are our research subjects. The study was to investigate the effects of UV-LEDs of different power densities on vitamin D production. There are 4 groups：0.1, 0.2, 0.4, 0.8mW/cm2 and the rats (n = 6 per group) were irradiated with different power densities twice a week for a total of 8 weeks. The results showed that serum 25(OH)D3 levels rapidly increased in all irradiated groups compared with those in the control group (P < 0.001 in all groups), and 25(OH)D3 level of the rats in groups of both 0.4 and 0.8 m W/cm2 were able to return to the initial level at the fourth week after irradiation, besides, the group of 0.4 mW/ W/cm2 can achieve and maintain the highest25(OH)D3 level and so as the group of 0.8 m W/cm2 as the continuing irradiation. We demonstrate that the proper irradiation density of UV-LED irradiation can increase the production of vitamin D in rats and does not adversely affect the skin of rats.

Citation Download Citation

Yunqi Li, Haixia Qiu, Hongyou Zhao, Biao Chang, Tengda Ji M.D., Yidi Liu, and Ying Gu "UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111903A (20 November 2019); https://doi.org/10.1117/12.2537833

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KEYWORDS

Bone

Skin

Ultraviolet radiation

Light emitting diodes

Calcium

Tissues

Ultraviolet light emitting diodes

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