Analysis of the relationship of the central tear meniscus area with the tear film symptomatology and stability

Carlos Garcia-Resua; Hugo Pena-Verdeal; Jacobo Garcia-Queiruga; Rosa Calo-Santiago; Maria J. Giraldez

doi:10.1117/12.2527348

3 October 2019 Analysis of the relationship of the central tear meniscus area with the tear film symptomatology and stability

Carlos Garcia-Resua, Hugo Pena-Verdeal, Jacobo Garcia-Queiruga, Rosa Calo-Santiago, Maria J. Giraldez

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Proceedings Volume 11207, Fourth International Conference on Applications of Optics and Photonics; 112071A (2019) https://doi.org/10.1117/12.2527348
Event: IV International Conference on Applications of Optics and Photonics (AOP 2019), 2019, Lisbon, Portugal

Abstract

Purpose: Tear film meniscus evaluation offers a non-invasive indication of the total volume of the tear. The aim of this study was to analyse the relationship between the central tear meniscus area with symptomatology and tear film stability. Material and methods: 120 participants who completed an OSDI questionnaire were enrolled in the study. After fluorescein instillation, two videos were recorded by a digital camera attached to a slit-lamp. The first video recorded the lower central portion of the tear meniscus (6 o’clock) with a short light beam (3x5mm), and the second one recorded the complete ocular surface obtaining the Break-Up time (BUT) and Maximum Blink Interval (MBI). A self-design program (FWCapture) was used to acquire the videos while the participants were requested to keep the eye open for as long as possible three times. Images were extracted from each video by a masked observer. From de first video, Central Tear Meniscus Area with fluorescein (CTMAF) was “manually” measured by using ImageJ software (command “<<freehand tool”). From the second video, BUT and MBI were determined by counting video frames then converted in seconds; both parameters were averaging using only the two most similar measurements. Results: CTMAF showed a negative correlation with OSDI score (Spearman Rho: p <0.001, r=-0.372). There was found a statistical difference in the CTMAF between OSDI subgroups (Kruskal-Wallis: p=0.001). CTMAF showed a positive correlation with BUT/MBI (Spearman Rho: both p ≤0.003, r≥0.246). Conclusions: Tear film volume showed a relationship with the symptomatology and tear film stability.

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Carlos Garcia-Resua, Hugo Pena-Verdeal, Jacobo Garcia-Queiruga, Rosa Calo-Santiago, and Maria J. Giraldez "Analysis of the relationship of the central tear meniscus area with the tear film symptomatology and stability", Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112071A (3 October 2019); https://doi.org/10.1117/12.2527348

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KEYWORDS

Eye

Video

Statistical analysis

Analytical research

Digital cameras

Digital video recorders

Image filtering

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