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9 March 2020 Microglia distribution and motility in human eyes measured with adaptive optics – optical coherence tomography (AO-OCT) (Conference Presentation)
Daniel X. Hammer, Ricardo Villanueva, Anant Agrawal, Osamah Saeedi, Zhuolin Liu
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Proceedings Volume 11218, Ophthalmic Technologies XXX; 1121818 (2020) https://doi.org/10.1117/12.2548639
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Microglia are central nervous system macrophages and the first responders to neural injury. Herein we characterize their distribution and motility in human eyes using a multimodal AO system. In healthy eyes, microglia are absent in the central macula up to ~5º eccentricity but their density increases monotonically at higher eccentricities. Microglia density decreases linearly with age. ILM microglia are relatively immobile for durations up to two weeks but their processes re-orient over timescales as short as minutes. The density, motility, and reactive state of microglia may serve as an ocular disease biomarker for early detection and progression monitoring.
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Daniel X. Hammer, Ricardo Villanueva, Anant Agrawal, Osamah Saeedi, and Zhuolin Liu "Microglia distribution and motility in human eyes measured with adaptive optics – optical coherence tomography (AO-OCT) (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121818 (9 March 2020); https://doi.org/10.1117/12.2548639
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KEYWORDS
Adaptive optics
Adaptive optics optical coherence tomography
Optical coherence tomography
Optical testing
Macula
Injuries
Nervous system
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