10 March 2020Fluorescence dosimetry for indoor-daylight photodynamic therapy: clinical results using wide-field imaging and point-probe measurements (Conference Presentation)
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Clinical use of photodynamic therapy (PDT) is widespread for treatment of actinic keratosis (AKs) based upon ALA induced Protoporphyrin IX (PpIX). Dosimetry of the PpIX levels at the point-of-care can help guide critical decisions in PDT, since studies have shown that initial PpIX accumulation and PDT-induced photobleaching serve as strong indicators for patient outcomes in treatment. Here, we present clinical results using a point-probe spectral dosimeter alongside a translational wide-field cellphone fluorescence system to study outcomes of indoor-daylight PDT for treatment of AKs. The outcomes of this study help advance adoption of point-of-care dosimetry for PDT guidance and helps establish threshold treatment parameters for indoor-daylight PDT.
Alberto J. Ruiz,Ethan P. M. LaRochelle, andBrian Pogue
"Fluorescence dosimetry for indoor-daylight photodynamic therapy: clinical results using wide-field imaging and point-probe measurements (Conference Presentation)", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122007 (10 March 2020); https://doi.org/10.1117/12.2546997
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Alberto J. Ruiz, Ethan P. M. LaRochelle, Brian Pogue, "Fluorescence dosimetry for indoor-daylight photodynamic therapy: clinical results using wide-field imaging and point-probe measurements (Conference Presentation)," Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122007 (10 March 2020); https://doi.org/10.1117/12.2546997