Arefeh Sherafati,1 Adam T. Eggebrechthttps://orcid.org/0000-0002-6320-2676,1 Tracy M. Burns-Yocum,2 Heather M. Lugar,1 Anagha Narayanan,1 Tasha Doty,1 Alexandra M. Svoboda,1 Mariel L. Schroeder,1 Abraham Z. Snyder,1 Mwiza Ushe,1 Joseph P. Culver,1 Tamara Hershey1
1Washington Univ. School of Medicine in St. Louis (United States) 2Indiana Univ. (United States)
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Current gold standard neuroimaging tools lack either necessary temporal resolution (PET) or optimal safety due to contraindications (fMRI) for measuring the neural mechanisms underlying the effects of deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD). In this study, we validate the feasibility of High-Density Diffuse Optical Tomography (HD-DOT) for mapping the cortical activity of the PD patients with their STN DBS ON and OFF during auditory and visual tasks and during resting state.
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Arefeh Sherafati, Adam T. Eggebrecht, Tracy M. Burns-Yocum, Heather M. Lugar, Anagha Narayanan, Tasha Doty, Alexandra M. Svoboda, Mariel L. Schroeder, Abraham Z. Snyder, Mwiza Ushe, Joseph P. Culver, Tamara Hershey, "Mapping deep brain stimulation’s impact on cortical networks using high-density diffuse optical tomography (Conference Presentation)," Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260A (9 March 2020); https://doi.org/10.1117/12.2546903