Intra-tumor heterogeneity of glioblastoma samples revealed by visible light optical coherence microscopy (Conference Presentation)

Antonia Lichtenegger; Johanna Gesperger; Barbara Kiesel; Thomas Roetzer; Pablo Eugui; Danielle J. Harper; Matthias Salas; Marco Augustin; Conrad W. Merkle; Christoph K. Hitzenberger; Georg Widhalm; Adelheid Wöhrer; Bernhard Baumann

doi:10.1117/12.2544612

9 March 2020 Intra-tumor heterogeneity of glioblastoma samples revealed by visible light optical coherence microscopy (Conference Presentation)

Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Wöhrer, Bernhard Baumann

Author Affiliations +

Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 112281T (2020) https://doi.org/10.1117/12.2544612
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We utilized a visible light optical coherence microscopy imaging (OCM) system to investigate the intra-tumor heterogeneity of glioblastoma samples. Using a broad visible spectrum an axial resolution of 0.8 μm was achieved. Objective lenses with short focal lengths were integrated to achieve high transverse resolution. Large field of view images were acquired using an automatic moving x-y-stage. Attenuation maps were calculated from OCM data and cell-density evaluations were performed from corresponding histological sections. Cell density and attenuation data were evaluated. Our analysis revealed intra-tumor heterogeneity by varying cell densities and attenuation coefficients throughout the tumorous areas.

Conference Presentation

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Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Wöhrer, and Bernhard Baumann "Intra-tumor heterogeneity of glioblastoma samples revealed by visible light optical coherence microscopy (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112281T (9 March 2020); https://doi.org/10.1117/12.2544612

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KEYWORDS

Visible radiation

Optical coherence microscopy

Optical coherence tomography

Signal attenuation

Light scattering

Tissue optics

Brain

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