Ultrafast imaging of cardiac electromechanical wave propagation with volumetric optoacoustic tomography

Çağla Özsoy; Ali Özbek; Xosé Luís Deán-Ben; Daniel Razansky

doi:10.1117/12.2545890

17 February 2020 Ultrafast imaging of cardiac electromechanical wave propagation with volumetric optoacoustic tomography

Çağla Özsoy, Ali Özbek, Xosé Luís Deán-Ben, Daniel Razansky

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124028 (2020) https://doi.org/10.1117/12.2545890
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Understanding the mechanisms of cardiac disorders largely depends on availability of multi-dimensional and multiparametric imaging methods capable of quantitative assessment of cardiac morphology and function. The imaging modalities commonly employed in cardiac research, such as ultrasonography and magnetic resonance imaging, are lacking sufficient contrast and/or spatio-temporal resolution in 3D in order to reveal the multi-scale nature of rapid electromechanical activity in a beating heart. Our recently developed volumetric optoacoustic tomography (VOT) platform offers versatile observations of the heart function with rich optical contrast at otherwise unattainable temporal and spatial resolutions. Herein, we further advance the imaging performance by developing compressed acquisition scheme to boost the temporal resolution of VOT into the kilohertz range, thus enabling 3D mapping of electromechanical wave propagation in the heart. Experiments in isolated mouse hearts were performed by exciting the entire imaged tissue volume with nanosecond-duration laser pulses at 1 kHz repetition rate pulse operating at 532 nm and sparse tomographic signal sampling using a custom-made 512-element spherical matrix ultrasound array. By analyzing the strain maps obtained from the rapid VOT image sequence, it was possible to quantify the phase velocity of the electromechanical cardiac waves, in good agreement with previously reported values.

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Çağla Özsoy, Ali Özbek, Xosé Luís Deán-Ben, and Daniel Razansky "Ultrafast imaging of cardiac electromechanical wave propagation with volumetric optoacoustic tomography", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124028 (17 February 2020); https://doi.org/10.1117/12.2545890

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KEYWORDS

Heart

Tomography

Optoacoustics

Transducers

Ultrafast imaging

Wave propagation

3D image processing

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