FTIR Study On The Secondary Structure Of Mucin From Mucinous Cystadenoma Of The Ovary

Keng Shen; Paochen Wu; Weij in Zhou; Fuan Liu; Hai Guo; Jinguang Wu

doi:10.1117/12.969393

1 December 1989 FTIR Study On The Secondary Structure Of Mucin From Mucinous Cystadenoma Of The Ovary

Keng Shen, Paochen Wu, Weij in Zhou, Fuan Liu, Hai Guo, Jinguang Wu

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969393
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

The mucinous cystadenoma, a common benign neoplasm of the ovary, may sometime bring about a fatal outcome known as pseudomyxoma peritonei which is characterized by massive accumulation of mucinous substance in the peritoneal cavity, resulting in extensive adhesions, chronic progressive intestinal obstruction and finally death of the patient. Surgical approach to this condition proves to be a palliative procedure. Repeated operation can only remove part of the geletinous material and reaccumulation of mucus within 1-2 years after the initial surgery is almost a rule. In view of the benign histologic nature of the disease, chemotherapy, either systemic or intraperitoneal, and radiotherapy are generally ineffective in arresting the progression of the pathologic process and preventing the reaccumulation of mucus. Therefore, the only hope lies on the introduction into the peritoneal cavity some agents which may dissolve the accumulated mucin, relieve the intestinal obstruction, and consequently, prolong and even save the life f the patient. Based on this conception, sporadic articles by a few authors(1,2)ap-peared in the literature reporting their clinical experience with different mucolytic agents. However, some blindness would inevitably be involved in such investigations due to the lack of a comprehensive understanding of the chemical structures of the substance. The purpose of the present paper is to report our preliminary results of study of the secondary structures of mucin secreted by this special type of tumor.

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Keng Shen, Paochen Wu, Weij in Zhou, Fuan Liu, Hai Guo, and Jinguang Wu "FTIR Study On The Secondary Structure Of Mucin From Mucinous Cystadenoma Of The Ovary", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969393

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KEYWORDS

FT-IR spectroscopy

Ovary

Spectroscopy

Chemical analysis

Fourier transforms

Infrared radiation

Surgery

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