Endoscopic optic-axis mapping of white matter fiber tracts using polarization-sensitive optical coherence tomography

Damon T. DePaoli; Daniel C. Côté; Brett E. Bouma; Martin Villiger

doi:10.1117/12.2577859

5 March 2021 Endoscopic optic-axis mapping of white matter fiber tracts using polarization-sensitive optical coherence tomography

Damon T. DePaoli, Daniel C. Côté, Brett E. Bouma, Martin Villiger

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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116290S (2021) https://doi.org/10.1117/12.2577859
Event: SPIE BiOS, 2021, Online Only

Abstract

We present a small rotational fiber probe capable of endoscopically imaging the optic axis of white matter fiber bundles, deep in the brain, using a state-of-the-art polarization-sensitive optical coherence tomography system. The probe is easily modifiable to be housed by, or attached to, clinical instruments routinely descended into the brain (i.e. cannulas for deep brain stimulation electrodes or biopsy needles.) The optic axis contrast, stemming from the birefringent myelinated axons, informs about the location and orientation of white matter fiber bundles. This information can provide surgical guidance to neurosurgeons through its comparison with preoperative magnetic resonance imaging and diffusion tensor imaging.

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Damon T. DePaoli, Daniel C. Côté, Brett E. Bouma, and Martin Villiger "Endoscopic optic-axis mapping of white matter fiber tracts using polarization-sensitive optical coherence tomography", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116290S (5 March 2021); https://doi.org/10.1117/12.2577859

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KEYWORDS

Optical coherence tomography

Brain mapping

Endoscopy

Imaging systems

Brain

Polarization

Light scattering

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