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5 March 2021 Optimization of diffuse correlation spectroscopy instrumental and experimental parameters based on precision targets
Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Jonas B. Fischer, Martina Giovannella, Marta Zanoletti, Fabio Ferri, Fabrizio Martelli, Alberto Dalla Mora, Davide Contini, Stanislaw Wojtkiewicz, Hamid Dehghani, Udo M. Weigel, Turgut Durduran
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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390X (2021) https://doi.org/10.1117/12.2578237
Event: SPIE BiOS, 2021, Online Only
Abstract
Diffuse correlation spectroscopy (DCS) is an emerging diffuse optical technique that quantifies microvascular blood flow. In spite of the wide range of clinical/research applications, DCS instrumentation is not yet standardized. In this study, we have analyzed the effect of experimental parameters as the measurement duration time and the number of detectors, at different photon count-rates, on the precision of a DCS experiment. This provides a recipe for finding device and experimental settings that optimize the precision while balancing cost and temporal resolution.
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Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Jonas B. Fischer, Martina Giovannella, Marta Zanoletti, Fabio Ferri, Fabrizio Martelli, Alberto Dalla Mora, Davide Contini, Stanislaw Wojtkiewicz, Hamid Dehghani, Udo M. Weigel, and Turgut Durduran "Optimization of diffuse correlation spectroscopy instrumental and experimental parameters based on precision targets", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390X (5 March 2021); https://doi.org/10.1117/12.2578237
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KEYWORDS
Spectroscopes
Blood circulation
Temporal resolution
Tissue optics
Light scattering
Near infrared spectroscopy
Photon counting
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