Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder; Melissa M. Wu; Nisan Ozana; Davide Tamborini; Maria Angela Franceschini; Stefan A. Carp

doi:10.1117/12.2577787

5 March 2021 Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa M. Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan A. Carp

Author Affiliations +

Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410F (2021) https://doi.org/10.1117/12.2577787
Event: SPIE BiOS, 2021, Online Only

Abstract

The ability of diffuse correlation spectroscopy (DCS) to measure tissue perfusion paves the way for monitoring cerebral blood flow (CBF) non-invasively. However, during measurements on human forehead, the measured blood flow index (BFi) is susceptible to contamination due to the blood flow in extracerebral tissue. Time domain DCS addresses this problem by selecting photons based on their travel time to obtain BFi at various depths. We have determined the gate start time(s) and width(s) that can lead to optimal sensitivity of BFi to CBF during actual measurements on human subjects through simulations. The simulated parameters were compared with measurement data.

Conference Presentation

Citation Download Citation

Dibbyan Mazumder, Melissa M. Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, and Stefan A. Carp "Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410F (5 March 2021); https://doi.org/10.1117/12.2577787

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Monte Carlo methods

Blood circulation

Spectroscopy

Brain

Tissue optics

Geometrical optics

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years