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5 March 2021 Photoacoustic imaging and finite element strain analysis as novel tools for assessing the roles of aqueous veins and perilimbal sclera in intraocular pressure regulation
Guan Xu, Linyu Ni, John Reisterer, Wonsuk Kim, Huaizhou Wang, Layla Berry, Wei Zhang, Yannis Paulus, Xueding Wang, Sayoko Moroi, Alan Argento
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Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 1164509 (2021) https://doi.org/10.1117/12.2577878
Event: SPIE BiOS, 2021, Online Only
Abstract
We developed a photoacoustic imaging (PAI) and finite element analysis (FEA) approach for characterizing the biomechanical behaviors of the aqueous veins and perilimbal sclera, and their roles in the regulation of intraocular pressure (IOP). 3D architectures of the sclera and the aqueous veins perfused with indocyanine green have been resolved by an optical resolution PAI system. The tissue ans strain fields were quantified using FEA. The performance of the proposed method has been validated by tensile test in scleral tissue. The methods have shown the capability of resolving the strain gradients at the vein-sclera interface during the manipulation of IOP.
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Guan Xu, Linyu Ni, John Reisterer, Wonsuk Kim, Huaizhou Wang, Layla Berry, Wei Zhang, Yannis Paulus, Xueding Wang, Sayoko Moroi, and Alan Argento "Photoacoustic imaging and finite element strain analysis as novel tools for assessing the roles of aqueous veins and perilimbal sclera in intraocular pressure regulation", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 1164509 (5 March 2021); https://doi.org/10.1117/12.2577878
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KEYWORDS
Finite element methods
Veins
Sclera
Photoacoustic imaging
Tissues
Tissue optics
Optical coherence tomography
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