Laser-generated titanium nitride nanoparticles for biomedical applications: Synthesis and comprehensive biological study

Anton A. Popov; Ivan V. Zelepukin; Victoria O. Shipunova; Gleb V. Tikhonowski; Elena A. Popova-Kuznetsova; Aziz B. Mirkasymov; Sergey M. Klimentov; Andrei V. Kabashin; Sergey M. Deyev

doi:10.1117/12.2586411

5 March 2021 Laser-generated titanium nitride nanoparticles for biomedical applications: Synthesis and comprehensive biological study

Anton A. Popov, Ivan V. Zelepukin, Victoria O. Shipunova, Gleb V. Tikhonowski, Elena A. Popova-Kuznetsova, Aziz B. Mirkasymov, Sergey M. Klimentov, Andrei V. Kabashin, Sergey M. Deyev

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Proceedings Volume 11675, Synthesis and Photonics of Nanoscale Materials XVIII; 116750I (2021) https://doi.org/10.1117/12.2586411
Event: SPIE LASE, 2021, Online Only

Abstract

Owing to a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) constitute a promising candidate for nanomedicine. However, their potential is still underexplored due to difficulties of synthesis of stable biocompatible colloids of TiN NPs. Here, we provide results of elaboration of laser-ablative synthesis of TiN NPs in liquids which can solve the problem. Laser-ablated TiN NPs have strong plasmonic peak in near-IR. We also present their first comprehensive biocompatibility assessment. The obtained results evidence high safety of laser-synthesized TiN NPs for biological systems, which promises a major advancement of phototheranostic modalities on their basis.

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Anton A. Popov, Ivan V. Zelepukin, Victoria O. Shipunova, Gleb V. Tikhonowski, Elena A. Popova-Kuznetsova, Aziz B. Mirkasymov, Sergey M. Klimentov, Andrei V. Kabashin, and Sergey M. Deyev "Laser-generated titanium nitride nanoparticles for biomedical applications: Synthesis and comprehensive biological study", Proc. SPIE 11675, Synthesis and Photonics of Nanoscale Materials XVIII, 116750I (5 March 2021); https://doi.org/10.1117/12.2586411

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