This paper proposes an unpaired medical image translation framework between portal-venous phase and non-contrast CT volumes. Image-to-image translation has immense potential application values in medical image analysis fields, such as segmentation. Currently, many deep learning-based segmentation methods have been proposed on contrast-enhanced CT volumes. However, for the patients who have contrast medium allergy, only non-contrast CT is available. Thus, segmentation using non-contrast CT volumes is also an important task. Image translation from non-contrast CT to contrast-enhanced CT is an alternative to solve this problem. In this work, we employed the cycle-consistent adversarial network (CycleGAN) and unpaired image-to-image network (UNIT) for image translation. To evaluate the translation performance for multi-organ segmentation, we trained a segmentation model using contrast-enhanced CT images with U-Net. Our experimental results show that image translation has a positive influence on multi-organ segmentation. The segmentation actuaries greatly improved by applying the image translation.
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