Photoacoustic delivery and imaging methods in PDT

Luis G. Arnaut; Catarina S. Lobo; M. Inês P. Mendes; Diogo A. Pereira

doi:10.1117/12.2609789

4 March 2022 Photoacoustic delivery and imaging methods in PDT

Luis G. Arnaut, Catarina S. Lobo, M. Inês P. Mendes, Diogo A. Pereira

Proceedings Volume 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; 119400A (2022) https://doi.org/10.1117/12.2609789
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Homogeneous drug delivery to solid tumors is difficult to achieve because of biological barriers in the tumor and of its elevated interstitial fluid pressure. We investigated the distribution of a photosensitizer (redaporfin) in orthotopic 4T1 and subcutaneous CT26 tumors using photoacoustic tomography. Redaporfin has a distinct photoacoustic spectrum that allows for its localization and relative quantification. Whereas CT26 tumors uptake a large amount of redaporfin, 4T1 tumors have redaporfin mostly in their periphery. We exposed 4T1 tumors to high-intensity, broadband photoacoustic waves and show that the amount of redaporfin in 4T1 tumors increases after 5 minutes of exposure. Photoacoustic waves are a promising non-invasive method to increase drug delivery to solid tumors.

Conference Presentation

Citation Download Citation

Luis G. Arnaut, Catarina S. Lobo, M. Inês P. Mendes, and Diogo A. Pereira "Photoacoustic delivery and imaging methods in PDT", Proc. SPIE 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, 119400A (4 March 2022); https://doi.org/10.1117/12.2609789

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