Many eye diseases, such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP), can cause abnormalities at both central and peripheral regions of the fundus. Therefore, a wide field fundus imaging is desirable for screening, diagnosis, and treatment evaluation of eye diseases. The traditional fundus imaging device which uses trans-pupillary illumination has 30° to 60° field of view. In the trans-pupillary illumination, illumination path and observing path are typically separated by using different portions of the pupil to minimize the effect of reflectance artifact. Therefore, transpupillary illumination limits the field of view because only the central part can be used for imaging purpose. Transpalpebral illumination has been explored as an alternative approach to deliver light to the interior of the eye through the pars-plana, which enables capturing a wide portion of the fundus. Without the need of pharmacologic pupil dilation, a 150° visual angle fundus image was achieved. Previous studies implemented trans-palpebral illumination using a broadband LED. As it is well known that the transmission of long wavelength light is much higher than the short wavelength. Therefore, trans-palpebral illumination based fundus images are red oriented, with compromised image quality for visualizing retinal vasculatures. We have demonstrated the trans-palpebral illumination for the ultra-wide field fundus imaging. We report here the feasibility of using independent green and red illumination power controls to compensate for the difference of spectral efficiency. The color balanced trans-pars-planar illumination significantly increased dynamic range of the fundus camera.
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