Towards pulsatile multilayer tissue phantoms

Sophie Jenne; Hans Zappe; Susanna Herdt

doi:10.1117/12.2608118

2 March 2022 Towards pulsatile multilayer tissue phantoms

Sophie Jenne, Hans Zappe, Susanna Herdt

Proceedings Volume 11951, Design and Quality for Biomedical Technologies XV; 1195102 (2022) https://doi.org/10.1117/12.2608118
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Tissue-mimicking optical phantoms are used for a wide variety of purposes, especially the development and routine quality control of bio-optical measurement techniques. We present here the fabrication and evaluation of a multilayer human skin phantom with a pulsating vascular network. The skin-mimicking phantom comprises the three upper skin layers (dermis, epidermis and hypodermis) and the corresponding blood vessels. It is based on polydimethylsiloxane (PDMS) in which absorption and scattering are induced by adding ink as an absorber and titanium dioxide particles as scattering agent. The vessels are fabricated by inserting wires of different diameter at different heights into a mold frame before adding the uncured PDMS and removing them after curing. A circulatory system is constructed using micro-displacement pumps that are connected to the artificial blood vessels. The expansion of the microvasculature in pure PDMS is monitored using a microscope.

Citation Download Citation

Sophie Jenne, Hans Zappe, and Susanna Herdt "Towards pulsatile multilayer tissue phantoms", Proc. SPIE 11951, Design and Quality for Biomedical Technologies XV, 1195102 (2 March 2022); https://doi.org/10.1117/12.2608118

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