An ultrasound-guided diffuse fluorescence tomography for small animals

Xin Wang; Teng Pan; Yuhong Liu; Jianwei Zhang

doi:10.1117/12.2612012

8 July 2022 An ultrasound-guided diffuse fluorescence tomography for small animals

Xin Wang, Teng Pan, Yuhong Liu, Jianwei Zhang

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Proceedings Volume 12282, 2021 International Conference on Optical Instruments and Technology: Optoelectronic Measurement Technology and Systems; 122820V (2022) https://doi.org/10.1117/12.2612012
Event: 2021 International Conference on Optical Instruments and Technology, 2022, Online Only

Abstract

Diffuse fluorescence tomography (DFT) is an emerging optical imaging tool for in-vivo observation of organisms and small-animal. Especially, dynamic diffuse fluorescence tomography can provide contrast-enhanced and comprehensive information for tumor diagnosis and staging with the pharmacokinetic image. However, the conventional reconstruction algorithms for DFT always suffers from low spatial resolution. Multi-modality imaging methods have been proposed to integrate DFT with other imaging modalities with in general intricate and costly experimental apparatus. We developed a dual-modality system that combines the ultrasound imaging and DFT which is simple and low-cost with no ionization damage. The results in phantom experiments demonstrate that with the a priori guidance of ultrasound imaging, the quantitativeness and spatial resolution of the fluorescence image can be considerably improved.

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Xin Wang, Teng Pan, Yuhong Liu, and Jianwei Zhang "An ultrasound-guided diffuse fluorescence tomography for small animals", Proc. SPIE 12282, 2021 International Conference on Optical Instruments and Technology: Optoelectronic Measurement Technology and Systems, 122820V (8 July 2022); https://doi.org/10.1117/12.2612012

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KEYWORDS

Luminescence

Ultrasonography

Optical fibers

Fluorescence tomography

Image segmentation

Tissues

Imaging systems

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