Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment

Dmitry G. Revin; Robert A. Byers; Meng Q. Duan; Wei Li; Stephen J. Matcher

doi:10.1117/12.2647563

14 March 2023 Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment

Dmitry G. Revin, Robert A. Byers, Meng Q. Duan, Wei Li, Stephen J. Matcher

Author Affiliations +

Proceedings Volume 12352, Photonics in Dermatology and Plastic Surgery 2023; 123520B (2023) https://doi.org/10.1117/12.2647563
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Atopic dermatitis is a chronic, relapsing inflammatory skin disease, which has one of the highest prevalence rates in the world. It is widely believed to be driven by deficiencies in the skin barrier layer, which is provided by the stratum corneum. The stratum corneum thickness determines the absorption rate of topical treatments and may correlate with its barrier function of preventing allergen penetration. Here we demonstrate a free-space, portable Fourier domain visible-light optical coherence tomography (OCT) system to study the stratum corneum thickness (5-15 μm typically) in non-palmar human skin. We use a supercontinuum laser source, optimized for emission in the 500-700 nm range and achieve axial resolution of ~ 1 μm in tissue (for the refractive index n = 1.55 of the stratum corneum). Our system has ~ -85 dB sensitivity at an A-scan rate of 125 kHz and about 1 mW of optical power onto the skin. High-quality B-scans from various human skin sites are obtained, with a clearly resolved stratum corneum layer presenting as a hypoechogenic dark layer, similar to that found in palmar skin with traditional OCT systems.

Conference Presentation

Citation Download Citation

Dmitry G. Revin, Robert A. Byers, Meng Q. Duan, Wei Li, and Stephen J. Matcher "Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment", Proc. SPIE 12352, Photonics in Dermatology and Plastic Surgery 2023, 123520B (14 March 2023); https://doi.org/10.1117/12.2647563

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