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17 March 2023 Ultrafast laser surgery probe for sub-surface ablation: In vivo sub-epithelial ablation and biomaterial injection in canine vocal folds
Liam P. Andrus, Berk Camli, Ted Mau, Adela Ben-Yakar
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Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 1235408 (2023) https://doi.org/10.1117/12.2650592
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Creation of sub-epithelial voids within scarred vocal folds via ultrafast laser ablation may help in localization of injectable biomaterials towards an improved treatment for vocal fold scarring. Here, we investigated the feasibility of this technique by performing surgery in two adult canines using a miniaturized ultrafast laser surgery system. We identified ~2×2-mm2 voids ~110 μm beneath the epithelium surface using in situ endoscopic imaging and follow-up two-photon imaging and histology. We confirmed localization of an injectable model-biomaterial into a subset of these voids with fluorescence imaging. Future long-term studies on large animals will utilize the surgery system to further assess the clinical viability of such a vocal fold scarring therapy.
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Liam P. Andrus, Berk Camli, Ted Mau, and Adela Ben-Yakar "Ultrafast laser surgery probe for sub-surface ablation: In vivo sub-epithelial ablation and biomaterial injection in canine vocal folds", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 1235408 (17 March 2023); https://doi.org/10.1117/12.2650592
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KEYWORDS
Laser ablation
Laser therapeutics
Surgery
Ultrafast lasers
Laser beam diagnostics
In vivo imaging
Two photon imaging
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