Ultrafast laser surgery probe for sub-surface ablation: In vivo sub-epithelial ablation and biomaterial injection in canine vocal folds

Liam P. Andrus; Berk Camli; Ted Mau; Adela Ben-Yakar

doi:10.1117/12.2650592

17 March 2023 Ultrafast laser surgery probe for sub-surface ablation: In vivo sub-epithelial ablation and biomaterial injection in canine vocal folds

Liam P. Andrus, Berk Camli, Ted Mau, Adela Ben-Yakar

Author Affiliations +

Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 1235408 (2023) https://doi.org/10.1117/12.2650592
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Creation of sub-epithelial voids within scarred vocal folds via ultrafast laser ablation may help in localization of injectable biomaterials towards an improved treatment for vocal fold scarring. Here, we investigated the feasibility of this technique by performing surgery in two adult canines using a miniaturized ultrafast laser surgery system. We identified ~2×2-mm2 voids ~110 μm beneath the epithelium surface using in situ endoscopic imaging and follow-up two-photon imaging and histology. We confirmed localization of an injectable model-biomaterial into a subset of these voids with fluorescence imaging. Future long-term studies on large animals will utilize the surgery system to further assess the clinical viability of such a vocal fold scarring therapy.

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Citation Download Citation

Liam P. Andrus, Berk Camli, Ted Mau, and Adela Ben-Yakar "Ultrafast laser surgery probe for sub-surface ablation: In vivo sub-epithelial ablation and biomaterial injection in canine vocal folds", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 1235408 (17 March 2023); https://doi.org/10.1117/12.2650592

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KEYWORDS

Laser ablation

Laser therapeutics

Surgery

Ultrafast lasers

Laser beam diagnostics

In vivo imaging

Two photon imaging

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