Fluorescence-guided and molecularly guided debridement: identifying devitalized and infected tissue in orthopaedic trauma

Jonathan Thomas Elliott; Eric Henderson; Samuel S. Streeter; Valentin Demidov; Xinyue Han; Yue Tang; J. Scott Sottosanti; Logan Bateman; Petr Brůža; Shudong Jiang; I. Leah Gitajn

doi:10.1117/12.2661243

14 March 2023 Fluorescence-guided and molecularly guided debridement: identifying devitalized and infected tissue in orthopaedic trauma

Jonathan Thomas Elliott, Eric Henderson, Samuel S. Streeter, Valentin Demidov, Xinyue Han, Yue Tang, J. Scott Sottosanti, Logan Bateman, Petr Brůža, Shudong Jiang, I. Leah Gitajn

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 1236108 (2023) https://doi.org/10.1117/12.2661243
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Following orthopaedic trauma, bone devitalization is a critical determinant of complications such as infection or nonunion. Intraoperative assessment of bone perfusion has thus far been limited. Furthermore, treatment failure for infected fractures is unreasonably high, owing to the propensity of biofilm to form and become entrenched in poorly vascularized bone. Fluorescence-guided surgery and molecularly-guided surgery could be used to evaluate the viability of bone and soft tissue and detect the presence of planktonic and biofilm-forming bacteria. This proceedings paper discusses the motivation behind developing this technology and our most recent preclinical and clinical results.

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Jonathan Thomas Elliott, Eric Henderson, Samuel S. Streeter, Valentin Demidov, Xinyue Han, Yue Tang, J. Scott Sottosanti, Logan Bateman, Petr Brůža, Shudong Jiang, and I. Leah Gitajn "Fluorescence-guided and molecularly guided debridement: identifying devitalized and infected tissue in orthopaedic trauma", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 1236108 (14 March 2023); https://doi.org/10.1117/12.2661243

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