Diffuse reflectance spectroscopy for optical guidance in neurosurgery and design of a multimodal optic probe

Alexandre Bédard; Pegah Eslami; Damon Depaoli; Mireille Quémener; Martin Parent; Daniel Côté

doi:10.1117/12.2649348

17 March 2023 Diffuse reflectance spectroscopy for optical guidance in neurosurgery and design of a multimodal optic probe

Alexandre Bédard, Pegah Eslami, Damon Depaoli, Mireille Quémener, Martin Parent, Daniel Côté

Author Affiliations +

Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 1236407 (2023) https://doi.org/10.1117/12.2649348
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The purpose is to determine whether diffuse reflectance spectroscopy (DRS) can provide optical guidance during deep brain stimulation (DBS) surgery. Experiments on monkey ex vivo brains have been performed to ensure DRS methods could differentiate white and gray matter. In this study, we use principal component analysis (PCA) to determine the composition of tissue in front of the stimulation electrode. Furthermore, our work tackles the mechanical consequences of implementing an optical probe in a DBS electrode. This multidisciplinary project shows that DRS can be used as a non-invasive, cost-effective and real-time tissue characterization.

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Alexandre Bédard, Pegah Eslami, Damon Depaoli, Mireille Quémener, Martin Parent, and Daniel Côté "Diffuse reflectance spectroscopy for optical guidance in neurosurgery and design of a multimodal optic probe", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 1236407 (17 March 2023); https://doi.org/10.1117/12.2649348

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KEYWORDS

Diffuse reflectance spectroscopy

Brain

Principal component analysis

Computer simulations

Electrodes

Resistance

Safety

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