In children with sickle cell disease, there is a clinical need for non-invasive quantification of the degree of hemometabolic stress in these patients to mitigate risk of stroke. Frequency-domain near-infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) measures of regional oxygen extraction fraction, cerebral blood flow, and cerebral metabolic rate of oxygen have potential to provide markers of cerebral metabolic stress. In this study, we characterize the intra-subject and inter-operator repeatability of these measures, and we correlate DCS measures of cerebral blood flow index against both arterial spin-labeled MRI and transcranial Doppler ultrasound in a cohort of pediatric SCD patients.
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