In-vivo animal deep brain imaging using needle-based optical coherence tomography

Tsung-Yi Tsai; De-Yi Chiou; Chun-Chieh Huang; Fu-Chiang Jan; Cheng-Yi Chang; Shuen-Cheng Chen; Yen-Chang Wang; Wei-Lun Lo; Kai-Hsiang Chen; Chun-I Yeh; Yu-Ten Ju; Hung-Chih Chiang; Chii-Wann Lin

doi:10.1117/12.3006576

20 September 2023 In-vivo animal deep brain imaging using needle-based optical coherence tomography

Tsung-Yi Tsai, De-Yi Chiou, Chun-Chieh Huang, Fu-Chiang Jan, Cheng-Yi Chang, Shuen-Cheng Chen, Yen-Chang Wang, Wei-Lun Lo, Kai-Hsiang Chen, Chun-I Yeh, Yu-Ten Ju, Hung-Chih Chiang, Chii-Wann Lin

Author Affiliations +

Proceedings Volume 12608, Biomedical Imaging and Sensing Conference; 1260809 (2023) https://doi.org/10.1117/12.3006576
Event: Optics and Photonics International Congress, 2023, Yokohama, Japan

Abstract

Parkinson's disease is a progressive neurodegenerative disease that leads to decreased secretion of nigrostriatal dopamine, which inhibits the activity of the brain's motor cortex, Deep brain stimulation (DBS) is currently the best treatment for patients who do not respond well to drug therapy. The subthalamic nucleus (STN) is the target area for the implanting deep brain electrical stimulation electrodes. Currently, the surgical navigation for DBS depends on pre-operative CT/MRI and intra-operative MER (microelectrode recording) to know whether the electrode has reached the target area, but MER only has non-directional signals. In this project, we developed Optical Coherence Tomography-guided DBS (OCTgDBS) technology, which can obtain real-time, high-resolution images from miniature pig brain, which can assist in the accuracy of navigation and positioning during DBS surgery. Finally, postoperative CT/MRI was used as the basis for positioning in the brain. The results demonstrate that the OCT has a potential to be optical guidance system for DBS.

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Tsung-Yi Tsai, De-Yi Chiou, Chun-Chieh Huang, Fu-Chiang Jan, Cheng-Yi Chang, Shuen-Cheng Chen, Yen-Chang Wang, Wei-Lun Lo, Kai-Hsiang Chen, Chun-I Yeh, Yu-Ten Ju, Hung-Chih Chiang, and Chii-Wann Lin "In-vivo animal deep brain imaging using needle-based optical coherence tomography", Proc. SPIE 12608, Biomedical Imaging and Sensing Conference, 1260809 (20 September 2023); https://doi.org/10.1117/12.3006576

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